This study aims to determine the effect of an extract of Moringa oleifera on systolic blood pressure, diastolic blood pressure and HDL. Hypertension is a condition when blood pressure has an increase which gives continued symptoms in a target organ in the body. Hypertension left untreated will lead to complications and health problems. Prevention by providing the extract of Moringa oleifera can reduce systolic blood pressure, diastolic blood pressure and increase HDL. This study uses an experimental method with a pre-posttest control group design. The population is hypertensive patients with hypercholesterolemia who participated in the prolanist program at Health Center. Sample technique uses probability sampling. The sample consisted of 32 respondents, and each group included 16 respondents. Each group was given intervention for 13 days. Systolic blood pressure, diastolic blood pressure was measured on the 5th day, 10th day and 14th day and HDL measurements were carried out on the 14th day. On the 14th day, the intervention group systolic blood pressure showed 133.75 mmHg, diastolic blood pressure 83.25 mmHg, 56.69 mg / dL HDL, whereas the control group of systolic blood pressure showed 148.31 mmHg, diastolic blood pressure 89.19, HDL 49.44 mg / dL, so can be concluded that extract of Moringa oleifera can reduce systolic blood pressure, diastolic blood pressure, LDL, triglycerides and increase HDL.