Stroke is a clinical condition where the blood supply to the brain is interrupted suddenly, and there is a disturbance of nerve function that causes a decrease in consciousness or even death with an unstable hemodynamic status. The treatment aims to improve the distribution of oxygen throughout the body as described by improvements in hemodynamic status. Complementary therapy of sensory stimulation in the form of supportive religious audio increases the production of endorphin hormone which relaxes the heart, thereby increasing hemodynamic stability. The purpose of this study was to determine the effect of supportive religious audio on changes in hemodynamic status in stroke patients with impaired consciousness. Quasi-Experimental with pre-test and post-test non-equivalent control group design was used in this research. The sampling method used was purposive sampling with the number of samples of each group was 24 respondents. Data analysis was done using the Mann-Whitney test, Independent t-test, and Mannova test. The supportive religious audio was given 2 times a day, each time 30 minutes for 2 days. Results showed that there was no significant effect in providing pleasant spiritual sound for changing the hemodynamic status of stroke patients with impaired consciousness (p> 0.05). The mean changes in systolic blood pressure and heart rate in the intervention group were more than the changes in the control group. It could be concluded that supportive religious audio can be one of the complementary therapies in stroke patients with an impaired consciousness to stabilize hemodynamic status with a more optimal administration.