This study aims to determine a way to cure diabetic ulcer appropriately using a combination of modern dressing methods and ozone bagging therapy. The study was carried out experimentally with nonequivalent control group pretest and posttest design. Research subjects in the samples amounted to 25 respondents with grade II diabetic ulcer in the inflammatory phase who visited Pontianak Wound Care Clinic from November 2017 to March 2018. The research subjects were divided into 2 groups, namely the control group of 11 respondents and the intervention group numbered 14 respondents. The control group received wound care with modern antibacterial dressings namely Calcium Alginate, Cutimed Sorbact, Aquacell, Dalethyne, and Powder Iodosorp, while in the intervention group received the same wound care with modern dressing plus ozone bagging therapy with a concentration of 60-100µg / ml for 15 minutes. A combination of modern dressings and ozone bagging therapy had an effect on the wound healing process (p = 0.018), and also had a significant effect on the number of bacterial colonies (p = 0.006) so as to accelerate the healing process of grade II diabetic ulcer in the inflammatory phase, so it could be applied in providing care nursing diabetic ulcer patients.